S36 Hypoxia induced bronchodilation and hyperoxia induced bronchoconstriction in human airways

Introduction and objectives

Oxygen is often used inappropriately in hospital for patients without significant systemic hypoxia. In lung disease correcting hypoxia has become a key treatment target. Here for the first time we explore the effect of oxygen on airway tone in human lung models.

Methods

Human lung specimens were obtained at resection for cancer. Rings of human bronchi were mounted in 25 ml organ baths for continuous...