Conditional deletion of E11/podoplanin in bone protects against load-induced osteoarthritis

Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB osteocyte network contributes to the initiation and pathogenesis of osteoarthritis.We examined expression patterns of the glycoprotein E11/podoplanin by immunohistochemical labelling in murine, human...