Human TP53 gene polymorphisms among patients with hepatocellular carcinoma and chronic hepatitis B in Kenya

Missiani Ochwoto; Colins O. Oduma; Julius Oyugi; Dufton Mwaengo; Bartholomew N. Ondigo; James Kimotho; Alex Maiyo; Ruth M Nyangacha; Gladys Chesumbai; Elijah M. Songok

doi:https://doi.org/10.12688/f1000research.19416.1

doi.org/10.12688/f1000research.19416.1

Human TP53 gene polymorphisms among patients with hepatocellular carcinoma and chronic hepatitis B in Kenya

Missiani Ochwoto,

Colins O. Oduma

2

,

..., Elijah M. Songok

14

F1000Research

Volume: 8, Pages: 1364 - 1364

Published: Aug 6, 2019

Abstract

Background: Human TP53 is the gatekeeper for generation of human cells and is highly conserved. Any alteration/mutation to TP53 adversely affects the regulatory function of the protein, potentially resulting in cancer. This study investigated mutations in codons 7 and 249 of TP53, among patients with hepatocellular carcinoma (HCC) and chronic...

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Paper Details

Title

Human TP53 gene polymorphisms among patients with hepatocellular carcinoma and chronic hepatitis B in Kenya

DOI

doi.org/10.12688/f1000research.19416.1

Published Date

Aug 6, 2019

Journal

F1000Research

Volume

8

Pages

1364 - 1364

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