Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus

Here we investigate the function of Hedgehog (Hh) signalling in thymic  T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signalling promotes  T-cell development in the thymus and influences  T-cell effector subset distribution. Hh-mediated transcription in thymic  cells increased  T-cell number, and promoted their maturation and increased the NKT subset, whereas inhibition of Hh-mediated...