Structural Basis for Target-Directed MicroRNA Degradation
Abstract
MicroRNAs (miRNAs) broadly regulate gene expression through association with Argonaute (Ago), which also protects miRNAs from degradation. However, miRNA stability is known to vary and is regulated by poorly understood mechanisms. A major emerging process, termed target-directed miRNA degradation (TDMD), employs specialized target RNAs to selectively bind to miRNAs and induce their decay. Here, we report structures of human Ago2 (hAgo2) bound to...
Paper Details
Title
Structural Basis for Target-Directed MicroRNA Degradation
Published Date
Sep 1, 2019
Journal
Volume
75
Issue
6
Pages
1243 - 1255.e7
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