Hedgehog signaling promotes TH2 differentiation in naive human CD4 T cells

Hedgehog (Hh) proteins are intercellular signaling molecules that control development and tissue homeostasis. They also regulate thymocyte development and peripheral T-cell activation in mice and human subjects and have recently been shown to promote TH2 differentiation and function in mice.1Rowbotham N.J. Hager-Theodorides A.L. Cebecauer M. Shah D.K. Drakopoulou E. Dyson J. et al.Activation of the Hedgehog signaling pathway in T-lineage cells...