The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease

Volume: 5, Issue: 1, Pages: 308 - 318
Published: Jan 1, 2019
Abstract
null null Introduction null Clinical trials on preclinical Alzheimer’s disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression. null null null Methods null Multivariate continuous data are simulated from a Bayesian joint mixed-effects model fit to data from the...
Paper Details
Title
The relative efficiency of time-to-progression and continuous measures of cognition in presymptomatic Alzheimer's disease
Published Date
Jan 1, 2019
Volume
5
Issue
1
Pages
308 - 318
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