Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
Abstract
Ubiquitin (Ub) signaling requires the sequential interactions and activities of three enzymes, E1, E2, and E3. Cdc34 is an E2 that plays a key role in regulating cell cycle progression and requires unique structural elements to function. The molecular basis by which Cdc34 engages its E1 and the structural mechanisms by which its unique C-terminal extension functions in Cdc34 activity are unknown. Here, we present crystal structures of Cdc34...
Paper Details
Title
Structural insights into E1 recognition and the ubiquitin-conjugating activity of the E2 enzyme Cdc34
Published Date
Jul 24, 2019
Journal
Volume
10
Issue
1
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