Original paper

IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise

Science56.90
Volume: 365, Issue: 6449, Pages: 176 - 180
Published: Jul 12, 2019
Abstract
Elevated levels of type I interferon (IFN) during pregnancy are associated with intrauterine growth retardation, preterm birth, and fetal demise through mechanisms that are not well understood. A critical step of placental development is the fusion of trophoblast cells into a multinucleated syncytiotrophoblast (ST) layer. Fusion is mediated by syncytins, proteins deriving from ancestral endogenous retroviral envelopes. Using cultures of human...
Paper Details
Title
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise
Published Date
Jul 12, 2019
Journal
Volume
365
Issue
6449
Pages
176 - 180
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