Ins2 gene bursting activity defines a mature β-cell state

Pages: 702589
Published: Jul 14, 2019
Abstract
null Heterogeneity within specific cell types is common and increasingly apparent with the advent of single-cell transcriptomics. Transcriptional and functional cellular specialization has been described for insulin-secreting β-cells of the endocrine pancreas, including so-called extreme β-cells exhibiting >2 fold higher insulin gene activity. However, it is not yet clear whether β-cell heterogeneity is stable or reflects dynamic cellular...
Paper Details
Title
Ins2 gene bursting activity defines a mature β-cell state
Published Date
Jul 14, 2019
Journal
Pages
702589
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