In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies
Abstract
Cilia are highly conserved and ubiquitously expressed organelles. Ciliary defects of genetic origins lead to ciliopathies, in which retinal degeneration (RD) is one cardinal clinical feature. In order to efficiently find and design new therapeutic strategies the underlying mechanism of retinal degeneration of three murine model was compared. The rodent models correspond to three emblematic ciliopathies, namely: Bardet-Biedl Syndrome (BBS),...
Paper Details
Title
In vivo phenotypic and molecular characterization of retinal degeneration in mouse models of three ciliopathies
Published Date
Sep 1, 2019
Journal
Volume
186
Pages
107721 - 107721
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