Glycomics

Glycoprotein

Cancer

Glycan

Glycosylation

Metastasis

Targeted therapy

Cancer therapy

Cancer treatment

Cancer research

Genetics

Bioinformatics

Computational biology

Medicine

Biology

Cancer Cell

This review provides insights on the impact of glycosylation in cancer biology and its influence in the current approaches of targeted cancer therapies in the clinical setting. The roles of glycosylation in cancer signaling, tumor progression, and metastasis are reviewed as well as glycans and glycan-binding proteins in tumor immunomodulation. Moreover, the latest reports on glycans influencing targeted therapeutic approaches in cancer are summarized. Finally, we discuss the future challenges of the field, outlining potential applications of glycan-based biomarkers for patient stratification and strategies for improving personalized cancer treatment.

Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?