Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2
Abstract
Kindlin-2 regulates integrin-mediated cell adhesion to and migration on the extracellular matrix. Our recent studies demonstrate important roles of kindlin-2 in regulation of mesenchymal stem cell differentiation and skeletal development. In this study, we generated adipose tissue-specific conditional knockout of kindlin-2 in mice by using Adipoq-Cre BAC-transgenic mice. The results showed that deleting kindlin-2 expression in adipocytes in mice...
Paper Details
Title
Lipoatrophy and metabolic disturbance in mice with adipose-specific deletion of kindlin-2
Published Date
Jul 11, 2019
Journal
Volume
4
Issue
13
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