Organization of DNA damage, excision repair, and mutagenesis in chromatin: A genomic perspective
Abstract
Genomic DNA is constantly assaulted by both endogenous and exogenous damaging agents. The resulting DNA damage, if left unrepaired, can interfere with DNA replication and be converted into mutations. Genomic DNA is packaged into a highly compact yet dynamic chromatin structure, in order to fit into the limited space available in the nucleus of eukaryotic cells. This hierarchical chromatin organization serves as both the target of DNA damaging...
Paper Details
Title
Organization of DNA damage, excision repair, and mutagenesis in chromatin: A genomic perspective
Published Date
Sep 1, 2019
Journal
Volume
81
Pages
102645 - 102645
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