High glucose microenvironment accelerates tumor growth via SREBP1-autophagy axis in pancreatic cancer

Diabetes is recognized to be a risk factor of pancreatic cancer, but the mechanism has not been fully elucidated. Sterol regulatory element binding protein 1 (SREBP1) is an important transcription factor involved in both lipid metabolism and tumor progression. However, the relationship between high glucose microenvironment, SREBP1 and pancreatic cancer remains to be explored. Clinical data and surgical specimens were collected. Pancreatic cancer...