Radiation-induced myocardial damage indicated by focal defect on 123I-MIBG SPECT.

Published on Jul 15, 2019in European Journal of Nuclear Medicine and Molecular Imaging7.081
· DOI :10.1007/S00259-019-04416-2
Takashi Norikane7
Estimated H-index: 7
(Kagawa University),
Yuka Yamamoto34
Estimated H-index: 34
(Kagawa University)
+ 4 AuthorsYoshihiro Nishiyama39
Estimated H-index: 39
(Kagawa University)
Sources
Abstract
📖 Papers frequently viewed together
4 Citations
7 Citations
References6
Newest
#1Kentaro Takanami (Tohoku University)H-Index: 11
#2Akira Arai (Tohoku University)H-Index: 7
Last. Kei Takase (Tohoku University)H-Index: 30
view all 8 authors...
Abstract Purpose To investigate long term changes in myocardial fatty acid metabolic impairment caused by chemoradiation-therapy (CRT). Materials and methods We investigated 12 esophageal cancer patients who underwent SPECT/CT using I-123-labeled fatty acid analog (BMIPP) at pre-CRT, pre-boost irradiation, 3-month post-CRT, and 1-year post-CRT. The myocardial uptake was measured using the defect score and the total percentage of uptake (%uptake), which were defined as the sum of the visual score...
5 CitationsSource
#1Rei Umezawa (Tohoku University)H-Index: 15
#2Kei Takase (Tohoku University)H-Index: 30
Last. Shogo Yamada (Tohoku University)H-Index: 36
view all 11 authors...
We evaluated radiation-induced myocardial damage using iodine-123 β-methyl-iodophenyl pentadecanoic acid (I-123 BMIPP) scintigraphy. Between May 2010 and April 2011 we performed I-123 BMIPP scintigraphy for patients who had maintained complete response to curative radiotherapy (RT) for esophageal cancer for more than six months. We compared the area of the myocardium in the RT fields with that of reduced I-123 BMIPP uptake using a 15-segment model that is based on axial computed tomography (CT) ...
12 CitationsSource
Late myocardial damage induced by radiotherapy has become an important issue in radio-oncology since several studies have demonstrated increased incidence of cardiovascular disease following radiotherapy [1–3]. A 52-year-old man underwent radiochemotherapy and resection of oesophageal cancer in 2002. In June 2006, [F]fluorodeoxyglucose positron emission tomography (FDG-PET)was performed for staging of newly detected oral cancer. While FDG-PET was unsuspicious in the head and neck area, increased...
18 CitationsSource
#1Isis W. Gayed (University of Texas MD Anderson Cancer Center)H-Index: 17
#2H. Helen Liu (University of Texas MD Anderson Cancer Center)H-Index: 28
Last. Zhongxing LiaoH-Index: 87
view all 10 authors...
The detection of myocardial perfusion abnormalities after radiation therapy (RT) has been investigated previously in patients with lymphoma and breast cancer. However, the prevalence and association of such abnormalities with RT in esophageal cancer patients have not been investigated previously. Methods: The prevalence of myocardial perfusion abnormalities detected using gated myocardial perfusion imaging (GMPI) in patients with esophageal cancer after RT (RT group) was compared with that in pa...
104 Citations
#1Keiichi Jingu (Tohoku University)H-Index: 22
#2Tomohiro Kaneta (Tohoku University)H-Index: 20
Last. Shogo Yamada (Tohoku University)H-Index: 36
view all 15 authors...
Purpose: We evaluated the clinical significance of focal increased uptake in the basal myocardium on F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with esophageal cancer after radiotherapy. Methods and Materials: Between August 2004 and July 2005, a total of 64 patients who had been irradiated for thoracic esophageal cancer underwent FDG-PET at least three months after the completion of chemoradiotherapy. Some patients showed increased FDG uptake in the basal portion of...
75 CitationsSource
Abstract Purpose: To look for early and late signs of cardiac side effects of postoperative radiotherapy in patients with left-sided breast cancer. Methods and Materials: Seventeen left-sided primary (Stage I–III) breast cancer patients considered eligible were recruited. Their computer tomography-based dose planning showed a part of the heart's left ventricle irradiated with at least 85–95% of the total dose. Twelve patients were examined both before treatment and an average of 13 months later,...
120 CitationsSource
Cited By0
Newest