Phenotype

Cell

Transcriptome

Transdifferentiation

Transcription factor

Biology

Gene

Cancer

Gene expression

Cancer research

Genetics

Cancer Cell

Balanis, Sheu, et al. identify a small-cell neuroendocrine (SCN) state across various epithelial cancer types that shares genome-wide expression, methylation, and copy-number alteration patterns and associates with poor prognosis. SCN cancers have common vulnerabilities that, unexpectedly, are shared with blood cancers.

Pan-cancer Convergence to a Small-Cell Neuroendocrine Phenotype that Shares Susceptibilities with Hematological Malignancies