Efficacy of daikenchuto, a traditional Japanese Kampo medicine, for postoperative intestinal dysfunction in patients with gastrointestinal cancers: meta-analysis

Published on Jul 12, 2019in International Journal of Clinical Oncology2.879
· DOI :10.1007/S10147-019-01502-1
Masayoshi Hosaka1
Estimated H-index: 1
(Kyoto University),
Ichiro Arai5
Estimated H-index: 5
(Nihon Pharmaceutical University)
+ 6 AuthorsYoshiharu Motoo37
Estimated H-index: 37
(Kanazawa Medical University)
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Abstract
Background The Japan Society for Oriental Medicine makes a compilation of structured abstracts of randomized controlled trials (RCTs) of Kampo medicines available on its Evidence Reports of Kampo Treatment (EKAT) website.
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References25
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Intestinal dysfunction is one of the most common complications in patients after abdominal surgery. Daikenchuto (DKT), a traditional herbal medicine, is recently employed to improve postoperative intestinal dysfunction. The aim of this meta-analysis was to assess the efficacy of DKT in improving intestinal dysfunction after abdominal surgery.PubMed, Embase, and the Cochrane library were systematically searched to identify randomized controlled trails (RCTs) in adult patients undergoing abdominal...
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Background Chemotherapy-induced peripheral neuropathy (CIPN) is common and presents with persistent and challenging symptoms for which there is no effective means of prevention. This systematic review assessed the efficacy and safety of Goshajinkigan in the prevention of CIPN.
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Purpose Chemotherapy-induced peripheral neuropathy (CIPN) limits the dose of chemotherapy and reduces patients’ quality of life. Goshajinkigan is a Japanese herbal medicine used to alleviate neuropathy and general pain. A clinical guideline for prevention and management of CIPN stated that the prophylactic efficacy of goshajinkigan against CIPN was inconclusive. We conducted a systematic review to examine whether goshajinkigan prevents CIPN in patients receiving neurotoxic chemotherapy.
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#1Takeshi Nishino (University of Tokushima)H-Index: 5
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Background Daikenchuto (TJ-100), a traditional Japanese herbal medicine, is widely used in Japan. Its effects on gastrointestinal motility and microcirculation and its anti-inflammatory effect are known. The purpose of this prospective randomized controlled trial was to investigate the effect of TJ-100 after esophagectomy in esophageal cancer patients.
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#1Mitsuru Ishizuka (Dokkyo Medical University)H-Index: 20
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AIM: Although it has been widely demonstrated that administration of Daikenchuto (DKT), a traditional Japanese herbal medicine, improves gastrointestinal (GI) motility in patients undergoing abdominal surgery, few studies have investigated the efficacy of perioperative DKT administration for relief of postoperative ileus (PI) in patients undergoing surgery for GI cancer. Therefore, the aim of this study was to investigate whether perioperative administration of DKT relieves PI in patients with G...
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Background This exploratory trial was conducted to investigate whether daikenchuto accelerates the recovery of gastrointestinal function in patients undergoing open surgery for sigmoid or rectosigmoid cancer.
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Herbal medicines have been used in Japan for more than 1500 years and traditional Japanese medicines (Kampo medicines) are now fully integrated into the modern healthcare system. In total, 148 Kampo formulae are officially approved as prescription drugs and covered by the national health insurance system in Japan. However, despite their long track record of clinical use, the multi-targeted, multi-component properties of Kampo medicines, which are fundamentally different from Western medicines, h...
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#1Kozo Yoshikawa (University of Tokushima)H-Index: 19
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Last. Masaki Kitajima (International University of Health and Welfare)H-Index: 19
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Background Daikenchuto (DKT) has widely been used to improve abdominal symptoms by being expected to accelerate bowel motility. The purpose of this study is to examine the efficacy and safety of DKT for prevention of ileus and associated gastrointestinal symptoms after total gastrectomy. Study Design Two hundred and forty-five gastric cancer patients who underwent total gastrectomy were enrolled. Patients received either DKT (15.0 g/d) or matching placebo from postoperative days 1 to 12. Primary...
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#1Hidetoshi Katsuno (Fujita Health University)H-Index: 11
#2Koutarou Maeda (Fujita Health University)H-Index: 19
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Objective This exploratory trial was performed to determine whether Daikenchuto accelerates recovery of gastrointestinal function in patients undergoing open colectomy for colon cancer.
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#1Ichiro Arai (Nihon Pharmaceutical University)H-Index: 5
Background Japanese Kampo medicine is a traditional medicine with roots in ancient Chinese medicine. Because traditional physicians had been abolished in Japan, the present mainstream of Kampo treatment is that physicians who learned modern Western medicine prescribe Kampo extract products based on Western medical diagnosis. This situation is different from that in other east Asian countries, and the physicians require scientific clinical evidence. Methods Clinical studies were searched from lit...
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#1Yuma Wada (University of Tokushima)H-Index: 5
#2Kazunori Tokuda (University of Tokushima)H-Index: 3
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Introduction The tumor microenvironment is involved in acquiring tumor malignancies of colorectal liver metastasis (CRLM). We have reported that TU-100 (Daikenchuto) suppresses hepatic stellate cell (HSC) activation in obstructive jaundice. In this study, we report new findings as the direct and indirect inhibitory effects of TU-100 on cancer cell growth through the suppression of HSC activation. Materials and methods The HSCs (LX2) were cultured in colon cancer cells (HCT116 and HT29)-condition...
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#1Toru Aoyama (YCU: Yokohama City University)H-Index: 25
#2Hiroshi Tamagawa (YCU: Yokohama City University)H-Index: 11
Kampo medicine or Japanese/Chinese traditional herbal medicine has long been used for the treatment of various diseases, mainly in Asian countries. In recent years, Asian investigators have attempted to clarify the mechanism and clinical efficacy of Kampo medicine. This review summarizes the background, current status, and future perspectives of Kampo medicine in the multimodal treatment of gastrointestinal cancer. Regarding the clinical effect of Kampo medicine on postoperative dysfunction afte...
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Bei der Kampō-Medizin handelt es sich um eine mehr als1000 Jahre alte Form der japanischen Pflanzenheilkunde,welche sich durch ihre wissenschaftliche Evaluation sowie eine leichte Handhabung und gute Vertraglichkeitauszeichnet. Auf pragmatische Art und Weise verbindetsie die Erkenntnisse der wissenschaftlich fundierten Medizin mit traditionellen Konzepten wie der Zungen- undBauchdeckendiagnostik. Fur die Auswahl einer Kampō-Rezeptur spielen vor allem in Studien erbrachte Wirksamkeitsbelegen, sow...
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