Pharmacological characterization of the seven human NOX isoforms and their inhibitors
Abstract
NADPH oxidases (NOX) are a family of flavoenzymes that catalyze the formation of superoxide anion radical (O2•-) and/or hydrogen peroxide (H2O2). As major oxidant generators, NOX are associated with oxidative damage in numerous diseases and represent promising drug targets for several pathologies. Various small molecule NOX inhibitors are used in the literature, but their pharmacological characterization is often incomplete in terms of potency,...
Paper Details
Title
Pharmacological characterization of the seven human NOX isoforms and their inhibitors
Published Date
Sep 1, 2019
Journal
Volume
26
Pages
101272 - 101272
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