Effectiveness and Safety of Bronchial Thermoplasty in the Treatment of Severe Asthma

Rationale: Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle.Objectives: To evaluate the effectiveness and safety of BT versus a sham procedure in subjects with severe asthma who remain symptomatic despite treatment with high-dose inhaled corticosteroids and long-acting β2-agonists.Methods: A total of 288 adult subjects (Intent-to-Treat [ITT])...