Tumor hypoxia relief overcomes multidrug resistance and immune inhibition for self-enhanced photodynamic therapy

As the self-regulation of tumors in the tumor microenvironment (TME), the hypoxia becomes the limitation again in the last period of oxygen-rich inducing enhanced photodynamic therapy (PDT). In this study, a promising TME-triggered oxygen nanogenerator for self-enhanced PDT primed antitumor immunotherapy was designed via simple and green chemistry methods. Indocyanine green (ICG), as a multi-role photosensitizer, was applied in photothermal...