Management of suspected and confirmed recurrent venous thrombosis while on anticoagulant therapy. What next?

Suspected recurrent venous thromboembolism (VTE) is a common and vexing clinical problem. Confounding the diagnosis of recurrent VTE is a high frequency of residual VTE from prior VTE. The diagnosis of recurrent VTE must be established by comparing current imaging with past imaging to distinguish acute from chronic thrombosis. Next, we must ascertain if non-compliance was the cause of “apparent therapeutic failure” and if non-compliance is at...