Abstract 213: Development of a probody-drug conjugate targeting EpCAM for the treatment of solid tumors

Volume: 79, Issue: 13_Supplement, Pages: 213 - 213
Published: Jul 1, 2019
Abstract
Epithelial Cell Adhesion Molecule (EpCAM) is a glycosylated, 40-kDa type I transmembrane protein that plays a role in cell adhesion and cell signaling. EpCAM is an attractive target for antibody drug conjugate (ADC) development due to its overexpression on a variety of tumors of epithelial origin, including lung, colon, breast, ovarian, prostate and pancreatic cancers. In addition, EpCAM is enriched on tumor-initiating cells (TICs), which are...
Paper Details
Title
Abstract 213: Development of a probody-drug conjugate targeting EpCAM for the treatment of solid tumors
Published Date
Jul 1, 2019
Volume
79
Issue
13_Supplement
Pages
213 - 213
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