Adult stem cell deficits drive Slc29a3 disorders in mice
Abstract
Mutations exclusively in equilibrative nucleoside transporter 3 (ENT3), the only intracellular nucleoside transporter within the solute carrier 29 ( SLC29 ) gene family, cause an expanding spectrum of human genetic disorders (e.g., H syndrome, PHID syndrome, and SHML/RDD syndrome). Here, we identify adult stem cell deficits that drive ENT3-related abnormalities in mice. ENT3 deficiency alters hematopoietic and mesenchymal stem cell fates; the...
Paper Details
Title
Adult stem cell deficits drive Slc29a3 disorders in mice
Published Date
Jul 3, 2019
Journal
Volume
10
Issue
1
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