Physics

Internal medicine

Pathology

Adverse effect

Common Terminology Criteria for Adverse Events

Hyperthermic intraperitoneal chemotherapy

Quality of life (healthcare)

Cytoreductive surgery

Cancer

Nursing

Surgery

Refractory (planetary science)

Mesothelioma

Chemotherapy

Peritoneal mesothelioma

Ovarian cancer

Abdominal pain

Medicine

Astrobiology

The Lancet Oncology

Pressurised intraperitoneal aerosol chemotherapy (PIPAC) was introduced as a new treatment for patients with peritoneal metastases in November, 2011. Reports of its feasibility, tolerance, and efficacy have encouraged centres worldwide to adopt PIPAC as a novel drug delivery technique. In this Review, we detail the technique and rationale of PIPAC and critically assess its evidence and potential indications. A systematic search was done to identify all relevant literature on PIPAC published between Jan 1, 2011, and Jan 31, 2019.

Pressurised intraperitoneal aerosol chemotherapy: rationale, evidence, and potential indications