Urine 5MedC, a Marker of DNA Methylation, in the Progression of Chronic Kidney Disease

Alterations in DNA methylation may be involved in disease progression in patients with chronic kidney disease (CKD). Recent studies have suggested that 5-methyl-2'-deoxycytidine (5MedC) may be a marker of hypermethylation of DNA. Currently, there is no information available regarding the urine levels of 5MedC and its association with the progression of CKD.We examined the urine levels of 5MedC in spot urine samples from 308 patients with CKD...