Extracellular matrix type modulates mechanotransduction of stem cells
Abstract
Extracellular matrix (ECM) is comprised of different types of proteins, which change in composition and ratios during morphogenesis and disease progression. ECM proteins provide cell adhesion and impart mechanical cues to the cells. Increasing substrate stiffness has been shown to induce Yes-associated protein (YAP) translocation from the cytoplasm to the nucleus, yet these mechanistic studies used fibronectin only as the biochemical cue. How...
Paper Details
Title
Extracellular matrix type modulates mechanotransduction of stem cells
Published Date
Sep 1, 2019
Journal
Volume
96
Pages
310 - 320
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Notes
History