Emodin suppresses growth and invasion of colorectal cancer cells by inhibiting VEGFR2
Abstract
Emodin can effectively inhibit colorectal cancer cells, but the mechanism remains elusive. This study analyzed the changes of VEGFR2 signaling pathways in patients with colorectal cancer and the effects of emodin on HCT116 cells and xenograft tumor model. The expression levels of VEGFR2, PI3K, and p-AKT in colorectal cancer tissue samples were significantly higher than those in adjacent normal ones. Docking simulation confirmed that emodin bound...
Paper Details
Title
Emodin suppresses growth and invasion of colorectal cancer cells by inhibiting VEGFR2
Published Date
Sep 1, 2019
Volume
859
Pages
172525 - 172525
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