Abstract 4502: The role of A-to-I RNA editing in diversifying the microRNA functions in cancer

Both miRNAs and A-to-I RNA editing, a widespread nucleotide modification mechanism, have recently emerged as key players in cancer pathophysiology. However, the functional impact of RNA editing of miRNAs in cancer remains largely unexplored. Here, we systematically characterized the miRNA editing profiles of ~9000 samples across 20 cancer types from miRNA sequencing data of The Cancer Genome Atlas and identified adenosine-to-inosine (A-to-I) RNA...