Neuroepigenetic signatures of age and sex in the living human brain
Abstract
Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate gene transcription in the brain. Here, we measure in vivo expression of the epigenetic enzymes, histone deacetylases (HDACs), across healthy human aging and between sexes using [ 11 C]Martinostat positron emission tomography (PET) neuroimaging ( n = 41). Relative HDAC expression...
Paper Details
Title
Neuroepigenetic signatures of age and sex in the living human brain
Published Date
Jul 3, 2019
Journal
Volume
10
Issue
1
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