Metabolite Exchange between Mammalian Organs Quantified in Pigs
Abstract
Mammalian organs continually exchange metabolites via circulation, but systems-level analysis of this shuttling process is lacking. Here, we compared, in fasted pigs, metabolite concentrations in arterial blood versus draining venous blood from 11 organs. Greater than 90% of metabolites showed arterial-venous differences across at least one organ. Surprisingly, the liver and kidneys released not only glucose but also amino acids, both of which...
Paper Details
Title
Metabolite Exchange between Mammalian Organs Quantified in Pigs
Published Date
Sep 1, 2019
Journal
Volume
30
Issue
3
Pages
594 - 606.e3
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