The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

Volume: 10, Issue: 1
Published: Jul 2, 2019
Abstract
The deubiquitylase OTUD3 plays a suppressive role in breast tumorigenesis through stabilizing PTEN protein, but its role in lung cancer remains unclear. Here, we demonstrate that in vivo deletion of OTUD3 indeed promotes breast cancer development in mice, but by contrast, it slows down Kras G12D -driven lung adenocarcinoma (ADC) initiation and progression and markedly increases survival in mice. Moreover, OTUD3 is highly expressed in human lung...
Paper Details
Title
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
Published Date
Jul 2, 2019
Volume
10
Issue
1
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