SAT-101 TWO CASES OF ATYPICAL HEMOLYTIC UREMIC SYNDROME ASSOCIATED WITH HYBRID GENES IN CFH/CFHR GENE CLUSTER CAUSED BY NOVEL GENOMIC RECOMBINATION

Atypical hemolytic uremic syndrome (aHUS) is a rare disease resulting from dysregulation of complement pathway. Variants in the gene encoding complement factor H (CFH), the key regulator of complement pathway, are most frequently reported as the causes of aHUS. So far, six kinds of hybrid genes in CFH/CFHR gene cluster have been identified in aHUS and all the hybrid genes reportedly contain some part of CFH. We have previously established the...