The evolving (epi)genetic landscape of pancreatic neuroendocrine tumours

Volume: 26, Issue: 9, Pages: R519 - R544
Published: Aug 1, 2019
Abstract
Neuroendocrine neoplasms (NENs) are a relatively rare group of heterogeneous tumours originating from neuroendocrine cells found throughout the body. Pancreatic NENs (PanNENs) are the second most common pancreatic malignancy accounting for 1–3% of all neoplasms developing in the pancreas. Despite having a low background mutation rate, driver mutations in MEN1 , DAXX/ATRX and mTOR pathway genes ( PTEN , TSC1 / 2 ) are implicated in disease...
Paper Details
Title
The evolving (epi)genetic landscape of pancreatic neuroendocrine tumours
Published Date
Aug 1, 2019
Journal
Volume
26
Issue
9
Pages
R519 - R544
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