Development of an acute, short-term exposure model for phosgene

Volume: 29, Issue: 8, Pages: 604 - 615
Published: Jul 16, 2019
Abstract
Phosgene is classified as a chemical warfare agent, yet data on its short-duration high concentration toxicity in a nose-only exposure rat model is sparse and inconsistent. Hence, an exposure system for short-term/high concentration exposure was developed and characterized. Herein, we report the median lethal concentration (LC50) for a 10-min nasal exposure of phosgene in a 24-h rat survival model. Male Wistar rats (Envigo) weighing 180-210 g on...
Paper Details
Title
Development of an acute, short-term exposure model for phosgene
Published Date
Jul 16, 2019
Volume
29
Issue
8
Pages
604 - 615
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