Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology
Abstract
Motivation The composition and density of immune cells in the tumor microenvironment (TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow cytometry, immunohistochemistry staining or single-cell sequencing are often unavailable such that we rely on computational methods to estimate the immune-cell composition from bulk RNA-sequencing (RNA-seq) data. Various methods have been proposed recently, yet their...
Paper Details
Title
Comprehensive evaluation of transcriptome-based cell-type quantification methods for immuno-oncology
Published Date
Jul 1, 2019
Journal
Volume
35
Issue
14
Pages
i436 - i445
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Notes
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