Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

Volume: 79
Published: Jul 1, 2019
Abstract
Background: Most patients with advanced cancer eventually acquire resistance to targeted therapies, spurring extensive efforts to identify molecular events mediating therapy resistance. Here we demonstrate that many of these molecular events involve synthetic rescue (SR) genetic interactions, where the reduction in cancer cell viability caused by targeted gene inactivation is rescued by an adaptive alteration of another gene (the rescuer). null...
Paper Details
Title
Abstract LB-149: Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy
Published Date
Jul 1, 2019
Volume
79
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