Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
Abstract
Lysosomes receive and degrade cargo from endocytosis, phagocytosis and autophagy. They also play an important role in sensing and instructing cells on their metabolic state. The lipid kinase PIKfyve generates phosphatidylinositol-3,5-bisphosphate to modulate lysosome function. PIKfyve inhibition leads to impaired degradative capacity, ion dysregulation, abated autophagic flux and a massive enlargement of lysosomes. Collectively, this leads to...
Paper Details
Title
Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence
Published Date
Jan 1, 2018
Journal
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