A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations
Abstract
Tumour sequencing identifies highly recurrent point mutations in cancer driver genes, but rare functional mutations are hard to distinguish from large numbers of passengers. We developed a novel computational platform applying a multi-modal approach to filter out passengers and more robustly identify putative driver genes. The primary filter identifies enrichment of cancer mutations in CATH functional families (CATH-FunFams) – structurally and...
Paper Details
Title
A CATH domain functional family based approach to identify putative cancer driver genes and driver mutations
Published Date
Jan 22, 2019
Journal
Volume
9
Issue
1
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