Prevention of recurrent idiopathic gastroduodenal ulcer bleeding: a double-blind, randomised trial

Patients with a history of Helicobacter pylori-negative idiopathic bleeding ulcers have a considerable risk of recurrent ulcer complications. We hypothesised that a proton pump inhibitor (lansoprazole) is superior to a histamine 2 receptor antagonist (famotidine) for the prevention of recurrent ulcer bleeding in such patients.In this industry-independent, double-blind, randomised trial, we recruited patients with a history of idiopathic bleeding...