Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
Abstract
Methylation patterns of circulating cell-free DNA (cfDNA) contain rich information about recent cell death events in the body. Here, we present an approach for unbiased determination of the tissue origins of cfDNA, using a reference methylation atlas of 25 human tissues and cell types. The method is validated using in silico simulations as well as in vitro mixes of DNA from different tissue sources at known proportions. We show that plasma cfDNA...
Paper Details
Title
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
Published Date
Nov 29, 2018
Journal
Volume
9
Issue
1
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