Downregulation and upregulation

GLUT1

Biology

Gene

Endocrinology

Insulin

Cell growth

Metabolism

Cell biology

microRNA

Cancer research

Biochemistry

Competing endogenous RNA

Cell

Anaerobic glycolysis

Glucose transporter

Long non-coding RNA

Glycolysis

Journal of Cellular Physiology

Aerobic glycolysis (the Warburg effect) is a robust metabolic hallmark of most tumors, including oral squamous cell carcinoma (OSCC). Glucose transporter 1 (GLUT1), a major glucose transporter regulating the glucose uptake, is upregulated in OSCC and participated in the cell glycolysis of OSCC. The deregulation and function of noncoding RNAs in cancers have been widely reported. Reportedly, hsa_circular RNA (circRNA)_100290 (circ_SLC30A7) is significantly upregulated (fold change = 6.91, p &lt; 0.0000001) in OSCC. According to online tools prediction (miRWalk, miRanda, and Targetscan), miR‐378a could simultaneously target circRNA_100290 and GLUT1. Herein, the expression of circRNA_100290 and GLUT1 remarkably increased in oral tumor tissue specimens and cells. In OSCC cell lines, cell proliferation and glycolysis could be remarkably downregulated by circRNA_100290 silence, which could be rescued by GLUT1 overexpression. Conversely, miR‐378a expression could be remarkably inhibited in tumor tissue specimens and...

Circle RNA hsa_circRNA_100290 serves as a ceRNA for miR‐378a to regulate oral squamous cell carcinoma cells growth via Glucose transporter‐1 (GLUT1) and glycolysis