Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin
Abstract
In interphase eukaryotic cells, almost all heterochromatin is located adjacent to the nucleolus or to the nuclear lamina, thus defining nucleolus-associated domains (NADs) and lamina-associated domains (LADs), respectively. Here, we determined the first genome-scale map of murine NADs in mouse embryonic fibroblasts (MEFs) via deep sequencing of chromatin associated with purified nucleoli. We developed a Bioconductor package called NADfinder and...
Paper Details
Title
Two contrasting classes of nucleolus-associated domains in mouse fibroblast heterochromatin
Published Date
Jun 14, 2019
Journal
Volume
29
Issue
8
Pages
1235 - 1249
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