Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity
Abstract
null Glioblastoma heterogeneity and plasticity remain controversial, with proposed subtypes representing the average of highly heterogeneous admixtures of independent transcriptional states. Single-cell, protein-activity-based analysis allowed full quantification of >6,000 regulatory and signaling proteins, thus providing a previously unattainable single-cell characterization level. This helped identify four novel, molecularly distinct subtypes...
Paper Details
Title
Single-cell based elucidation of molecularly-distinct glioblastoma states and drug sensitivity
Published Date
Jun 19, 2019
Journal
Pages
675439
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