Original paper

Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells

Published: Jan 1, 2017
Abstract
Paracrine signals maintain developmental states and create cell-fate patterns in vivo, and influence differentiation outcomes in human embryonic stem cells (hESCs) in vitro. Systematic investigation of morphogen signaling is hampered by the difficulty of disentangling endogenous signaling from experimentally applied ligands. Here, we grow hESCs in micropatterned colonies of 1-8 cells (“μColonies”) to quantitatively investigate paracrine...
Paper Details
Title
Morphogen and community effects determine cell fates in response to BMP4 signaling in human embryonic stem cells
Published Date
Jan 1, 2017
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