Modulation of gold nanoparticle mediated radiation dose enhancement through synchronization of breast tumor cell population

The incorporation of high atomic number materials such as gold nanoparticles (GNPs) into tumor cells is being tested to enhance the local radiotherapy (RT) dose. It is also known that the radiosensitivity of tumor cells depends on the phase of their cell cycle. Triple combination of GNPs, phase of tumor cell population, and RT for improved outcomes in cancer treatment.We used a double-thymidine block method for synchronization of the tumor cell...