Production of Spliced Long Noncoding RNAs Specifies Regions with Increased Enhancer Activity
Abstract
Active enhancers in mammals produce enhancer RNAs (eRNAs) that are bidirectionally transcribed, unspliced, and unstable. Enhancer regions are also enriched with long noncoding RNA (lncRNA) transcripts, which are typically spliced and substantially more stable. In order to explore the relationship between these two classes of RNAs, we analyzed DNase hypersensitive sites with evidence of bidirectional transcription, which we termed eRNA-producing...
Paper Details
Title
Production of Spliced Long Noncoding RNAs Specifies Regions with Increased Enhancer Activity
Published Date
Nov 1, 2018
Journal
Volume
7
Issue
5
Pages
537 - 547.e3
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