Association of brain volume loss and long-term disability outcomes in patients with multiple sclerosis treated with teriflunomide

Background: Teriflunomide 14 mg significantly reduced brain volume loss (BVL) and confirmed disability worsening (CDW) compared with placebo in the TEMSO core study. Objective: To investigate the relationship between BVL from Baseline to Year 2 in the TEMSO core study and long-term CDW (Year 7) in the TEMSO long-term extension (NCT00803049). Methods: Structural Image Evaluation using Normalization of Atrophy determined BVL. Long-term CDW was...