Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
Abstract
The role of dysbiosis in food allergy (FA) remains unclear. We found that dysbiotic fecal microbiota in FA infants evolved compositionally over time and failed to protect against FA in mice. Infants and mice with FA had decreased IgA and increased IgE binding to fecal bacteria, indicative of a broader breakdown of oral tolerance than hitherto appreciated. Therapy with Clostridiales species impacted by dysbiosis, either as a consortium or as...
Paper Details
Title
Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy
Published Date
Jun 24, 2019
Journal
Volume
25
Issue
7
Pages
1164 - 1174
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