Fibroblast state switching orchestrates dermal maturation and wound healing
Abstract
Murine dermis contains functionally and spatially distinct fibroblast lineages that cease to proliferate in early postnatal life. Here, we propose a model in which a negative feedback loop between extracellular matrix (ECM) deposition and fibroblast proliferation determines dermal architecture. Virtual-tissue simulations of our model faithfully recapitulate dermal maturation, predicting a loss of spatial segregation of fibroblast lineages and...
Paper Details
Title
Fibroblast state switching orchestrates dermal maturation and wound healing
Published Date
Aug 1, 2018
Journal
Volume
14
Issue
8
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Notes
History